Information Related to the FOXG1 Research Foundation (FRF) Clinical Trial Planning
As the FOXG1 Research Foundation advances toward clinical trials for our FOXG1 gene replacement therapy, naturally, parents and caregivers have many questions. This page will be updated regularly to serve as a communication touch-point to answer Frequently Asked Questions.
Who will be able to participate in the trial?
Many parameters influence the design of clinical trials, including their size (number of patients). There are multiple criteria for participation in clinical trials, including clinical considerations and others, which are ultimately determined through a process of discussion with and approval by the FDA and other regulatory agencies. Once the study plan is finalized and a green light is received from the agency to initiate a clinical trial, enrollment is done via a randomized process, ensuring that we operate in full compliance with all rules and regulations. Enrollment in the clinical trial cannot be guaranteed.
Does involvement in FOXG1 studies impact enrollment?
The FOXG1 syndrome registry, Natural History Study, and other clinical research activities FRF will be conducting in 2025 (which do not involve treatment; these were presented at the 2024 parent conference) are essential for the design and execution of an optimal clinical trial. Participation in these activities does not guarantee enrollment in a future clinical trial; however, its contribution to the clinical trial cannot be overstated, and we deeply appreciate the community's continued active engagement and involvement.
What is the goal for the trial?
FRF's ultimate goal is to develop a safe and effective FDA-approved treatment for FOXG1 syndrome, which can be available to the broader FOXG1 patient community as quickly as possible. A clinical trial is an essential step on the way to achieving our goal, rather than being the goal itself.
We recognize that the trial size, which will be optimized for testing the safety and potential benefit of the treatment and enabling the fastest possible approval path if proven successful, is unlikely to accommodate the number of families interested in participating. We are determined to do everything we can to bring a treatment across the approval finish line so that it is available to the FOXG1 community as early as possible.
How can I stay informed and up to date on clinical trial information?
If you haven’t already, sign up for our newsletter and follow our social media communication channels. Any updates will be posted there. Sign Up Here. Please check your spam/junk folder for missed emails and add [email protected] to your contacts, along with other FRF email addresses you receive.
Will there be a clinical trial site near me?
The number and location of clinical trial sites (including countries) will be determined based on various considerations, and we cannot guarantee that a site will be available in close proximity to every family interested in participating. At the same time, FRF will do its best to minimize the impact of geographical considerations on trial enrollment (while recognizing that regulatory or legal considerations could affect international participation).
Will families need to pay to enroll their FOXG1 patient in the trial?
No. There is no fee or payment associated with participation in the clinical trial, and it is not possible to “purchase a spot” in the trial. The cost of the trial will be covered by FRF through the generous donations we receive from supporters.
How many patients will be enrolled in the trial?
The clinical trial design is underway and will be discussed with the FDA and other regulatory agencies later in 2025. FRF will update the community when additional information becomes available.
Is there anything I can do to increase the chances of my child being enrolled in the trial?
Participation in the clinical trial cannot be secured or guaranteed. Clinical trial design and logistical considerations are informed, among other things, by the data we have from the FOXG1 syndrome patient registry and the FOXG1 Natural History Study (NHS).
To contribute, please:
Make sure your child's FOXG1 syndrome registry profile is up to date, with their genetics report uploaded: https://foxg1.beneufit.com/.
Update your Citizen Health FOXG1 NHS account with the latest medical records. If you are in the U.S., Citizen Health will access the records for you. Outside the U.S., you can upload any recent hospitalization visit records: https://www.citizen.health/partners/foxg1.
Consider participating in clinical research activities FRF will be conducting in 2025 in preparation for the clinical trial. More information will be posted in the near future.
Stay informed! If you are not receiving emails from the FRF, sign up here.
Will a clinical trial be restricted to specific FOXG1 mutations?
Our gene therapy is designed to be potentially beneficial to the broad FOXG1 patient population that does not have two fully functional copies of the FOXG1 gene. We aim to open trial enrollment to as broad a spectrum of FOXG1 mutations as possible, pending safety considerations and approval by the regulatory agencies. Additional information will be provided when it becomes available.
Will there be an age limit for participation in the clinical trial?
Age range is one of many elements of clinical trial design that will be discussed with the regulatory agencies. We will seek to test the potential benefit of our gene therapy across a range of ages. Stay tuned for specific updates, which we will provide as they become available.
Will the FRF continue to update us on the progress?
As always, FRF will continue to update the FOXG1 community on the progress we are making. When the time comes to provide details about the clinical trial, including the enrollment process, we will be delighted to do so, as it will mark a huge milestone, signaling that we are very close to study initiation.
We have a lot of work ahead of us in 2025 to reach that stage, and we are excited to be pushing hard to get there as safely and quickly as possible!
What if I have additional questions?
If you have additional questions related to the FOXG1 gene therapy program, please click the button below and submit them through the form for consideration to be answered on this page. We will do our best to address every inquiry.